遗传学 (instant notes 系列) 2nd edtion

书名：Instant Notes Genetics (2nd edition)

作者：P. C. Winter, G. I. Hickey and H. L. Fletcher

PW: Department of Haematology, Belfast City Hospital, Belfast, UK
GH: Science Department, St. Mary’s University College, Belfast, UK
HF: School of Biology & Biochemistry, The Queen’s University of Belfast, Belfast, UK

Preface
Since the first edition, we have learned that humans have about 30 000 to 40 000 genes (it really is that accurate) compared to 26 000 in a plant, Arabidopsis thaliana, 19 000 in the nematode Caenorhabditis elegans, 13 600 in the fruitfly Drosophila melanogaster, and 5 800 in the yeast Saccharomyces cerevisie. If you know where in the human genome to look, the hard sequencing work is probably done for you. If you know how to use the data, you can make money. We have updated some sections to reflect the rapid advances made in the science of genetics, and have also increased the coverage of genetics related to us humans and our society. Some modern technology used to identify and study genetic diseases have been included (DNA microchips and real time PCR) and bioinformatics introduces the computerized analysis of the wealth of data from systematic genome sequencing and protein analysis. The old section “ Applications of Genetics” have been split into Human Genetics and Genetics and Society. The former has more details of genetic disorders, and a new topic, epigenetics, about persistent, even heritable, changes in gene expression without changes in DNA sequence. It is these that make the process of cloning animals so unpredictable. Genetics and society includes topics causing public concern. There is an updated section on the Human Genome Mapping Project, and Transgenics (Genetically Modified Organisms) are now a separate topic. Ethical Issues have become a new topic to assist readers to make up your own minds about what controls you would like to see imposed. We have concentrated on providing the factual scientific information and the questions, argument and dilemmas which must be faced by anyone trying to decide what is right or wrong in the uses of modern genetics. The pace of advances in genetics has not slackened, and the applications of genome sequence data will continue to have a large effect on our lives for several decades.

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